A collection of software tools developed to support clinical neuromodeling, particularly computational psychiatry, computational neurology, and computational psychosomatics.


Lars Kasper1,2, Steffen Bollmann3, Andreea O. Diaconescu1, Chloe Hutton4, Jakob Heinzle1, Sandra Iglesias1, Tobias U. Hauser4,5, Miriam Sebold6, Zina-Mary Manjaly7, Klaas P. Pruessmann2, Klaas E. Stephan1,4,8, Kay H.Brodersen9, Christoph Mathys10


Before contacting, please try the following:


  1. Look at the FAQ.
  2. A lot of questions have also been discussed on the mailinglist (, which has a searchable archive.
  3. For new requests, we would ask you to submit them as issues on our github release page for TAPAS.

Estimated cost



Stable release v2.7.4.1, GNU General Public License (GPL, Version 3)

TAPAS is a collection of algorithms and software tools that are developed by the Translational Neuromodeling Unit (TNU, Zurich) and collaborators. These tools have been developed to support translational neuroscience, particularly concerning the application of neuroimaging and computational modeling to research questions in psychiatry, neurology and psychosomatics. TAPAS is written in MATLAB and presently is comprises the next tools:

  • HGF: Hierarchical Gaussian Filtering (Bayesian inference on computational processes from observed behaviour).
  • MICP: Mixed-effects inference on classification performance.
  • MPDCM: Massively parallel DCM (efficient integration of dynamical systems, i.e., DCMs, using massive parallelization).
  • PhysIO: Physiological noise correction of fMRI data.
  • SEM: SERIA Model for Eye Movements (saccades and anti-saccades) and Reaction Times
  • VBLM: Variational Bayes for linear regression models.



1Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Wilfriedstrasse 6, 8032 Zurich, Switzerland
2Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland
3Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, 4072, Australia
4Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK
5Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1 B 5EH, UK
6Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin, 10117 Berlin, Germany
7Department of Neurology, Schulthess Clinic, 8008 Zurich, Switzerland
8Max Planck Institute for Metabolism Research, 50931 Cologne, Germany
9Google, Inc.
10Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom